Isabella Rossellini grew up in Paris and Rome. At the age of 19, she moved to New York where she became a translator and later became a reporter for RAI-Italian Television. Their popular segments led to appearances as New York correspondent for the weekly Italian comedy show The Other Sunday, starring Roberto Benigni.
Her modeling career began when she was photographed by Bruce Weber for British Vogue and Bill King for American Vogue. Since then she has worked with the most important photographers in the industry, including Richard Avedon, Steven Meisel, Helmut Newton, Peter Lindbergh, Norman Parkinson and Eva Arnold. She has appeared on the cover of such magazines as Vogue, Elle, Marie Claire, Bazaar and Vanity Fair. An exhibition of photographs by Rossellini, portrait of a woman took place in March 1988 in the Museum of Modern Art in Paris.